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We reported that SMCs and endothelial cells with ATGL deficiency showed vulnerable and pro-inflammatory phenotypes in vitro. 10 The known causes of TGCV thus far are genetic as well as acquired deficiency of adipose triglyceride lipase (ATGL), which is a rate-limiting enzyme of hydrolysis of TG. TGCV was recently identified as an orphan disease in Europe in 2019 (Orphanet ORPHA Number: 565612). 8 9 Since this discovery, we launched the Japan TGCV study group as a governmental rare disease project to develop diagnostic criteria and specific treatments. We initially reported that among Japanese patients requiring cardiac transplantation, defective hydrolysis of intracellular triglyceride (TG) results in diffuse narrowing coronary atherosclerosis with massive accumulation of TG, but not cholesterol in vascular smooth muscle cells (SMCs) and endothelial cells. Triglyceride deposit cardiomyovasculopathy (TGCV) is a novel disease concept. 5 6 Given the poor responses to any invasive revascularisation therapies and medical therapy, cardiovascular mortality is 10–20 times higher in dialysis patients than in the general population. 4 Although medical therapies have evolved dramatically during the previous three decades, statins have little effect on HD-related lipid abnormalities and the improvement of prognosis among these populations. 1–3 Despite development of therapeutic procedures, such as percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG), the mortality rate among patients on HD is still high. Patients on haemodialysis (HD) are at a higher risk of developing cardiovascular disease (CVD), which is a leading cause of death and accounts for approximately 30%–35% of all-cause mortality among patients on HD. Professor Tetsuya Amano, Cardiology, Aichi Medical University, Nagakute 480-1195, Japan amanotaichi-med-u.ac.jp
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The Met’s Summer Encore presentations will include full open captions. Tenor Juan Diego Flórez stars alongside her as the young Swiss villager who conquers her heart-and a slew of high Cs-in Laurent Pelly’s charming staging. In this encore performance from 2008, madcap comedy and impeccable coloratura come together in Natalie Dessay’s indelible portrayal of the feisty tomboy Marie, raised by a regiment of French soldiers. Rounding out the cast are soprano Susanna Phillips, baritones Lucas Meachem and Alexey Lavrov, and bass Matthew Rose as the rambunctious gang of bohemian friends in Franco Zeffirelli’s classic staging, an audience favorite for more than 40 years. In this encore performance from 2018, soprano Sonya Yoncheva and tenor Michael Fabiano star as the young lovers Mimì and Rodolfo in Puccini’s timeless love story. Pinkerton, sung by tenor Marcello Giordani.
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Soprano Patricia Racette stars as Cio-Cio-San, the trusting and innocent young geisha who disastrously falls in love with American Navy lieutenant B. Andrew Davis conducts.Īnthony Minghella’s beautiful, atmospheric production of Puccini’s tragedy returns to cinemas this summer in a stunning performance recorded live from the Metropolitan Opera in 2009. Baritone Nathan Gunn co-stars as Danilo, and Broadway legend Kelli O’Hara is Valencienne, in a dazzling production directed and choreographed by Tony Award–winner Susan Stroman. The great Renée Fleming stars as the heiress who captivates all of Paris in Lehár’s enchanting operetta, recorded live from the Metropolitan Opera in 2015. Please visit your local cinema website for the most up-to-date information related to their health-and-safety measures.įIND PARTICIPATING THEATER Summer Encores Schedule in the United States
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Four popular operas from the Met’s award-winning series of live cinema presentations return to theaters this summer.